Premium
Genome‐wide postnatal changes in immunity following fetal inflammatory response
Author(s) -
Costa Daniel,
Bonet Núria,
Solé Amanda,
González de AledoCastillo José Manuel,
Sabidó Eduard,
Casals Ferran,
Rovira Carlota,
Nadal Alfons,
Marin Jose Luis,
Cobo Teresa,
Castelo Robert
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15578
Subject(s) - inflammation , acquired immune system , systemic inflammation , umbilical cord , transcriptome , fetus , immune system , proteomics , proteome , innate immune system , biology , immunology , immunity , cord blood , gestational age , medicine , pregnancy , bioinformatics , gene expression , gene , genetics
The exposure to a fetal inflammatory response (FIR) is often followed by a postnatal systemic inflammation, increasing the risk of perinatal brain injury. We profiled the transcriptome and proteome in neonatal dried blood spots from extremely preterm newborns (< 28 weeks of gestation), affected and unaffected by FIR. The observed molecular changes confirm the activation of the innate immune system in FIR‐affected neonates and reveal an impairment of their adaptive immunity.