Genome‐wide postnatal changes in immunity following fetal inflammatory response | Zendy

Costa Daniel | Zendy; Bonet Núria | Zendy; Solé Amanda | Zendy; González de AledoCastillo José Manuel | Zendy; Sabidó Eduard | Zendy; Casals Ferran | Zendy; Rovira Carlota | Zendy; Nadal Alfons | Zendy; Marin Jose Luis | Zendy; Cobo Teresa | Zendy; Castelo Robert | Zendy

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Genome‐wide postnatal changes in immunity following fetal inflammatory response

Author(s) -

Costa Daniel,

Bonet Núria,

Solé Amanda,

González de AledoCastillo José Manuel,

Sabidó Eduard,

Casals Ferran,

Rovira Carlota,

Nadal Alfons,

Marin Jose Luis,

Cobo Teresa,

Castelo Robert

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15578

Subject(s) - inflammatory response , immunity , biology , immunology , fetus , immune system , genome , inflammation , pregnancy , genetics , gene

The exposure to a fetal inflammatory response (FIR) is often followed by a postnatal systemic inflammation, increasing the risk of perinatal brain injury. We profiled the transcriptome and proteome in neonatal dried blood spots from extremely preterm newborns (< 28 weeks of gestation), affected and unaffected by FIR. The observed molecular changes confirm the activation of the innate immune system in FIR‐affected neonates and reveal an impairment of their adaptive immunity.

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