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The anti‐STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death
Author(s) -
Boriero Diana,
Carcereri de Prati Alessandra,
Antonini Lorenzo,
Ragno Rino,
Sohji Kazuo,
Mariotto Sofia,
Butturini Elena
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15577
Subject(s) - microglia , neuroinflammation , neurodegeneration , myricetin , stat1 , neurotoxicity , myr , chemistry , hypoxia (environmental) , microbiology and biotechnology , biology , phosphorylation , medicine , biochemistry , immunology , flavonoid , inflammation , toxicity , kaempferol , disease , organic chemistry , oxygen , gene , antioxidant , genome
STAT1 is critically involved in microglia activation and represents a suitable target for the prevention and treatment of neurodegeneration. Microglia respond to hypoxia and switch toward M1 pro‐inflammatory phenotype. Excessive microglia activation contributes to neuronal death. Here, we show that myricetin inhibits STAT1 signaling and switches off hypoxia‐induced M1 microglia polarization preventing neuronal death.