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A guide to assessing cellular senescence in vitro and in vivo
Author(s) -
GonzálezGualda Estela,
Baker Andrew G.,
Fruk Ljiljana,
MuñozEspín Daniel
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15570
Subject(s) - senescence , biology , cellular senescence , phenotype , mechanism (biology) , microbiology and biotechnology , computational biology , neuroscience , bioinformatics , genetics , gene , philosophy , epistemology
Cellular senescence is a complex cell response to damage and stress that can impact the surrounding tissue. Senescent cells no longer proliferate and undergo particular phenotypic changes. However, their phenotype can be very variable, and identifying senescence remains a challenge. In this review, we provide a guide to assessing senescence confidently by describing the different biomarkers and an optimized strategy for their detection in cultures, tissues and in vivo .