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Matrix stiffness‐mediated effects on macrophages polarization and their LOXL2 expression
Author(s) -
Xing Xiaoxia,
Wang Yaohui,
Zhang Xi,
Gao Xiangyu,
Li Miao,
Wu Sifan,
Zhao Yan,
Chen Jie,
Gao Dongmei,
Chen Rongxin,
Ren Zhenggang,
Zhang Kezhi,
Cui Jiefeng
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15566
Subject(s) - downregulation and upregulation , macrophage polarization , extracellular matrix , chemistry , microbiology and biotechnology , stiffness , cancer research , macrophage , materials science , in vitro , medicine , biology , biochemistry , composite material , gene
Increased matrix stiffness strengthens M2 macrophage polarization and upregulates their HIF‐1α expression, which eventually causes LOXL2 upregulation in the polarized macrophages. The secreted LOXL2 from the polarized macrophages under higher stiffness stimulation, together with that from HCC cells, contributes to the formation of lung premetastatic niche in HCC.