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Metabolism as a central regulator of β‐cell chromatin state
Author(s) -
Vanderkruk Ben,
Hoffman Brad G.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15562
Subject(s) - chromatin , microbiology and biotechnology , biology , regulator , cell metabolism , gene expression , cell fate determination , regulation of gene expression , metabolism , cell , chromatin remodeling , cell type , transcription factor , gene , biochemistry
Pancreatic β‐cells are critical mediators of glucose homeostasis. Metabolites that are controlled by mitochondria are essential co‐factors in DNA and histone modification reactions. These modifications have impacts on gene expression. Thus, via these metabolites, changes in mitochondrial activity can alter gene expression. Metabolic disorders that alter levels of these metabolites thereby can affect β‐cell chromatin state, gene expression, and function.