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Exosomes as mediators of immune regulation and immunotherapy in cancer
Author(s) -
Kugeratski Fernanda G.,
Kalluri Raghu
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15558
Subject(s) - microvesicles , immune system , tumor microenvironment , exosome , cancer , myeloid derived suppressor cell , biology , cancer immunotherapy , immunotherapy , myeloid , immunology , cancer research , context (archaeology) , cancer cell , suppressor , microrna , paleontology , biochemistry , genetics , gene
Exosomes provide signals that regulate the various stages of the cancer immunity cycle. Exosomes modulate key functions of lymphoid and myeloid cell populations of the tumor microenvironment, and can either support or restrain antitumor immunity. Notably, exosomes can also be engineered to elicit antitumor immune responses in cancer.