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Extracellular vesicles derived from inflamed murine colorectal tissue induce fibroblast proliferation via epidermal growth factor receptor
Author(s) -
Hasegawa Kana,
Kuwata Keiko,
Yoshitake Jun,
Shimomura Sayako,
Uchida Koji,
Shibata Takahiro
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15557
Subject(s) - epidermal growth factor receptor , cancer research , inflammatory bowel disease , colorectal cancer , colitis , epidermal growth factor , ulcerative colitis , cell growth , mapk/erk pathway , immunology , biology , medicine , cancer , receptor , signal transduction , microbiology and biotechnology , pathology , disease , genetics
We demonstrated that extracellular vesicles (EVs) secreted by murine colorectal tissue are internalized by fibroblasts. EVs derived from colitis model mice increased EGFR expression in NIH3T3 cells and promoted their proliferation through activation of the EGFR‐ERK signaling pathway. Our study offers new insights into the EV‐mediated pathogenesis of inflammatory bowel disease‐associated colorectal cancer, which may be helpful in developing new therapeutic strategies for inflammation‐associated tumors.