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Circulating BiP/Grp78 is a novel prognostic marker for sepsis‐mediated immune cell death
Author(s) -
Doerflinger Marcel,
Reljic Boris,
Menassa Joseph,
Nedeva Christina,
Jose Irvin,
Faou Pierre,
Mackiewicz Liana,
Mansell Ashley,
Pellegrini Marc,
Hotchkiss Richard,
Puthalakath Hamsa
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15552
Subject(s) - sepsis , immune system , programmed cell death , immunology , lipopolysaccharide , medicine , antibody , apoptosis , biomarker , cell , biology , biochemistry , genetics
Death of immune cells is a significant contributor to the pathology of polymicrobial sepsis. Diagnosis of sepsis‐induced lymphophenia is currently challenged by a lack of accurate biomarkers for the condition. Here, Hamsa Puthalakath and co‐authors report that lipopolysaccharide‐activated macrophages release the ER chaperone BiP (binding immunoglobin protein, also known as GRP78) into the extracellular milieu. This secreted form of BiP binds target cells through an unknown receptor and induces ER stress, resulting in apoptosis. Secreted circulating BiP could be used as a prognostic marker for immune cell death during sepsis.