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Cholesterol‐containing lipid nanodiscs promote an α‐synuclein binding mode that accelerates oligomerization
Author(s) -
Jakubec Martin,
Bariås Espen,
Furse Samuel,
Govasli Morten L.,
George Vinnit,
Turcu Diana,
Iashchishyn Igor A.,
MorozovaRoche Ludmilla A.,
Halskau Øyvind
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15551
Subject(s) - nanodisc , chemistry , cholesterol , lipid bilayer , biophysics , bilayer , surface plasmon resonance , residue (chemistry) , biochemistry , membrane , biology , materials science , nanotechnology , nanoparticle
Small, planar cell membrane mimics encased in a polymer called nanodiscs were prepared and allowed the monitoring of changes in α‐synuclein fibrillation in response to different lipids. The presence of cholesterol increased the affinity of the NAC region of α‐synuclein, a region implicated in detrimental fibrillation. When this interaction dominated, pathological fibrillation can proceed even in environments containing nonzwitterionic lipids which normally suppress the NAC‐specific interaction mode.