TADs enriched in histone H1.2 strongly overlap with the B compartment, inaccessible chromatin, and AT‐rich Giemsa bands | Zendy

SernaPujol Núria | Zendy; SalinasPena Mónica | Zendy; Mugianesi Francesca | Zendy; LopezAnguita Natalia | Zendy; TorrentLlagostera Francesc | Zendy; IzquierdoBouldstridge Andrea | Zendy; MartiRenom Marc A. | Zendy; Jordan Albert | Zendy

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TADs enriched in histone H1.2 strongly overlap with the B compartment, inaccessible chromatin, and AT‐rich Giemsa bands

Author(s) -

SernaPujol Núria,

SalinasPena Mónica,

Mugianesi Francesca,

LopezAnguita Natalia,

TorrentLlagostera Francesc,

IzquierdoBouldstridge Andrea,

MartiRenom Marc A.,

Jordan Albert

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15549

Subject(s) - chromatin , histone h1 , compartment (ship) , histone , chemistry , microbiology and biotechnology , biology , dna , biochemistry , oceanography , geology

An epigenetic characterization of Giemsa bands (G bands) revealed their utility as epigenetic units to investigate the differential distribution of linker histones. GC content is a strong driver in histone H1 distribution: H1X is enriched at high GC bands and H1.2 is abundant at low GC, compacted bands. Hi‐C analysis showed that TADs with a high H1.2/H1X ratio strongly overlap with B compartment, inaccessible chromatin and low‐GC bands.

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