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TADs enriched in histone H1.2 strongly overlap with the B compartment, inaccessible chromatin, and AT‐rich Giemsa bands
Author(s) -
SernaPujol Núria,
SalinasPena Mónica,
Mugianesi Francesca,
LopezAnguita Natalia,
TorrentLlagostera Francesc,
IzquierdoBouldstridge Andrea,
MartiRenom Marc A.,
Jordan Albert
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15549
Subject(s) - chromatin , epigenetics , biology , gc content , microbiology and biotechnology , histone , genome , genetics , gene
An epigenetic characterization of Giemsa bands (G bands) revealed their utility as epigenetic units to investigate the differential distribution of linker histones. GC content is a strong driver in histone H1 distribution: H1X is enriched at high GC bands and H1.2 is abundant at low GC, compacted bands. Hi‐C analysis showed that TADs with a high H1.2/H1X ratio strongly overlap with B compartment, inaccessible chromatin and low‐GC bands.