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The Ins and Outs of HOPS/TMUB1 in biology and pathology
Author(s) -
DellaFazia Maria Agnese,
Castelli Marilena,
Piobbico Danilo,
Pieroni Stefania,
Servillo Giuseppe
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15539
Subject(s) - microbiology and biotechnology , cell growth , biology , cytoplasm , cell cycle , centrosome , nucleophosmin , cell , gene knockdown , apoptosis , gene , genetics
HOPS/TMUB1 is an important player in controlling a number of important functions in the cell. Many investigations highlight the importance of HOPS/TMUB1 as protein modifier likewise SUMO or NEDD. HOPS/TMUB1 knockdown alters proper centrosome assembly, leading to genomic instability. HOPS/TMUB1 acts as a functional bridge between NPM and p19 Arf , providing new mechanistic insight into proliferation control. HOPS/TMUB1 acts on p53 stability, directing p53 mitochondrial apoptosis and its cytoplasmic localization.