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Evidence for a dominant‐negative mechanism in HARS1 ‐mediated peripheral neuropathy
Author(s) -
MeyerSchuman Rebecca,
Antonellis Anthony
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15538
Subject(s) - mechanism (biology) , peripheral neuropathy , peripheral , medicine , neuroscience , psychology , endocrinology , philosophy , epistemology , diabetes mellitus
Mullen et al . generate new models of pathogenic, dominant HARS1 mutations and show that they increase eIF2α phosphorylation and decrease protein translation in neurons. These results are consistent with a dominant‐negative mechanism of ARS‐mediated peripheral neuropathy. Comment on: https://doi.org/10.1111/febs.15449
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