Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes | Zendy

Staal Jens | Zendy; Driege Yasmine | Zendy; Haegman Mira | Zendy; Kreike Marja | Zendy; Iliaki Styliani | Zendy; Vanneste Domien | Zendy; Lork Marie | Zendy; Afonina Inna S. | Zendy; Braun Harald | Zendy; Beyaert Rudi | Zendy

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Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes

Author(s) -

Staal Jens,

Driege Yasmine,

Haegman Mira,

Kreike Marja,

Iliaki Styliani,

Vanneste Domien,

Lork Marie,

Afonina Inna S.,

Braun Harald,

Beyaert Rudi

Publication year - 2021

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.15522

Subject(s) - signal transduction , protein kinase c , space (punctuation) , microbiology and biotechnology , transduction (biophysics) , computer science , computational biology , mathematics , chemistry , biology , biochemistry , operating system

CARD‐CC/BCL10/MALT1 signaling complexes are activated by PKC‐mediated phosphorylation in response to specific upstream signals, leading to NF‐κB‐dependent gene expression. The caspase activation and recruitment domain (CARD)‐coiled‐coil domain (CC) family consists of four members and the PKC family of 9 members (subdivided in conventional, novel, and atypical subclasses). Here, we investigate the possible functional interactions between each specific PKC and CARD‐CC family member.

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