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Defining the combinatorial space of PKC::CARD‐CC signal transduction nodes
Author(s) -
Staal Jens,
Driege Yasmine,
Haegman Mira,
Kreike Marja,
Iliaki Styliani,
Vanneste Domien,
Lork Marie,
Afonina Inna S.,
Braun Harald,
Beyaert Rudi
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15522
Subject(s) - protein kinase c , signal transduction , microbiology and biotechnology , phosphorylation , biology , chemistry
CARD‐CC/BCL10/MALT1 signaling complexes are activated by PKC‐mediated phosphorylation in response to specific upstream signals, leading to NF‐κB‐dependent gene expression. The caspase activation and recruitment domain (CARD)‐coiled‐coil domain (CC) family consists of four members and the PKC family of 9 members (subdivided in conventional, novel, and atypical subclasses). Here, we investigate the possible functional interactions between each specific PKC and CARD‐CC family member.