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Progress and outlook in studying the substrate specificities of PARPs and related enzymes
Author(s) -
Suskiewicz Marcin J.,
Palazzo Luca,
Hughes Rebecca,
Ahel Ivan
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15518
Subject(s) - parp1 , poly adp ribose polymerase , serine , biology , enzyme , polymerase , computational biology , substrate (aquarium) , biochemistry , chemistry , ecology
ADP‐ribosylation is the addition of an ADP‐ribosyl group to a protein or a nucleic acid (DNA or RNA). In human cells, ADP‐ribosylation is mainly carried out by PARP1 and other members of the PARP family. Recent advances in studying PARPs and related enzymes point to a remarkable variety of ADP‐ribosylation targets, from protein amino acid residues of various types to terminal phosphates and bases of nucleic acids.