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Aminoglycoside antibiotics can inhibit or activate twister ribozyme cleavage
Author(s) -
Zhang Jun,
Liu Getong,
Sun Wenxia,
Chen Dongrong,
Murchie Alastair I.H.
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15517
Subject(s) - ribozyme , vs ribozyme , sisomicin , biology , hammerhead ribozyme , paromomycin , rna , guanine , hairpin ribozyme , binding site , cleavage (geology) , biochemistry , aminoglycoside , stereochemistry , chemistry , nucleotide , antibiotics , paleontology , fracture (geology) , gene , tobramycin , gentamicin
The twister ribozyme is a widely distributed self‐cleaving RNA enzyme. The aminoglycoside antibiotics are a clinically important class of flexible RNA‐binding ligands. Aminoglycoside binding can modulate ribozyme activity such that paromomycin inhibits and sisomicin activates the ribozyme. Drug binding induces allosteric changes to the tertiary structure of the RNA to hinder or facilitate interactions at the active site of the ribozyme slowing or accelerating bond scission.