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Narcissistic T cells: reactivity to self makes a difference
Author(s) -
Paprckova Darina,
Stepanek Ondrej
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15498
Subject(s) - antigen , reactivity (psychology) , biology , immune system , receptor , immunology , self tolerance , microbiology and biotechnology , peripheral tolerance , t cell , immune tolerance , medicine , genetics , alternative medicine , pathology
Relative differences in T‐cell self‐reactivity result in different T‐cell fate decisions during homeostasis and during inflammation. Numerous studies have shown that different levels of self‐reactivity shape outcomes of immune responses in both CD4 + and CD8 + T‐cell populations. Here we discuss recent advances related to T‐cell self‐reactivity and their potential implications in further basic and applied research.