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Model membrane systems to reconstitute immune cell signaling
Author(s) -
Céspedes Pablo F.,
Beckers Daniel,
Dustin Michael L.,
Sezgin Erdinc
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15488
Subject(s) - immunological synapse , immune system , biology , neuroscience , acquired immune system , synapse , innate immune system , cell , signal transduction , microbiology and biotechnology , computational biology , t cell , immunology , biochemistry , t cell receptor
Lipid membranes in cells fulfill a wide variety of functions essential to life. To dissect the exact roles of membranes and their components, experimental models capable of recapitulating their composition and biophysical properties are required. Here, we summarize and discuss different lipid bilayer models used for studying immune cell signaling with a specific focus on the immune synapse.