Premium
NOXA upregulation by the prohibitin‐binding compound fluorizoline is transcriptionally regulated by integrated stress response‐induced ATF3 and ATF4
Author(s) -
NúñezVázquez Sonia,
SánchezVera Ismael,
SauraEsteller José,
Cosialls Ana M.,
Noisier Anaïs F.M.,
Albericio Fernando,
Lavilla Rodolfo,
Pons Gabriel,
IglesiasSerret Daniel,
Gil Joan
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15480
Subject(s) - atf4 , integrated stress response , apoptosis , hela , activating transcription factor , unfolded protein response , downregulation and upregulation , atf3 , microbiology and biotechnology , transcription factor , biology , inhibitor of apoptosis , chemistry , programmed cell death , cell culture , translation (biology) , gene expression , biochemistry , promoter , messenger rna , genetics , gene
Fluorizoline is a new pro‐apoptotic agent that binds to prohibitins (PHB1 and PHB2) in the mitochondria and induces the integrated stress response (ISR). With phosphorylation of eukaryotic translation initiation factor 2α as the central event of this signaling pathway, fluorizoline induces ATF4 and ATF3. We demonstrated the key role of NOXA in fluorizoline‐induced apoptosis and identified ATF3 and ATF4 transcription factors as key mediators of NOXA upregulation and fluorizoline‐induced apoptosis.