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Eicosanoid biosynthesis in marine mammals
Author(s) -
Reisch Florian,
Kakularam Kumar Reddy,
Stehling Sabine,
Heydeck Dagmar,
Kuhn Hartmut
Publication year - 2021
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15469
Subject(s) - biology , gene , genome , arachidonic acid , triad (sociology) , epoxygenase , genetics , evolutionary biology , enzyme , biochemistry , psychology , psychoanalysis
Most marine mammals express functional cyclooxygenase (COX) and lipoxygenase (ALOX) isoforms. No ALOX12B and ALOXE3 orthologs are expressed in whales and dolphins, and these data suggest alternative mechanisms of epidermal differentiation in these animals. The ALOX15 orthologs of marine mammals adhere to the Triad concept and follow the Evolutionary Hypothesis of reaction specificity (arachidonic acid 12‐lipoxygenating enzymes).