Exploring a potential Achilles heel of Mycobacterium tuberculosis : defining the ClpC1 interactome

Protein degradation plays a vital role in the correct maintenance of a cell, not only under normal physiological conditions but also in response to stress. In the human pathogen Mtb , this crucial cellular task is performed by several ATPase associated with diverse cellular activities proteases including ClpC1P. Ziemski et al . performed a bacterial adenylate cyclase two‐hybrid screen to identify ClpC1 substrates and showed the Type II TA systems represent a major group of ClpC1‐interacting proteins. Comment on: https://doi.org/10.1111/febs.15335