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Membrane translocation at the ER: with a little help from my friends
Author(s) -
O'Keefe Sarah,
High Stephen
Publication year - 2020
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15309
Subject(s) - sec61 , endoplasmic reticulum , signal peptide , chromosomal translocation , secretory protein , microbiology and biotechnology , membrane protein , signal recognition particle , lumen (anatomy) , membrane , transport protein , chemistry , translocon , biology , secretion , peptide sequence , biochemistry , gene
The Sec61 complex is the proteinaceous pore through which one‐third of mammalian polypeptides access the lumen of the endoplasmic reticulum (ER) during their translocation across, or insertion into, the ER membrane. N‐terminal ER signal peptides mediate polypeptide targeting to, and opening of, the Sec61 channel in a substrate‐specific manner. Here, we discuss the recently defined features of ER signal peptides which necessitate the use of the accessory components Sec62 and Sec63 during the Sec61‐mediated cotranslational translocation of newly synthesized secretory proteins.