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Tailoring the immune response to the availability of nutrients
Author(s) -
Cattenoz Pierre B.,
Giangrande Angela
Publication year - 2020
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15304
Subject(s) - immune system , organism , biology , adipokine , secretion , nutrient , microbiology and biotechnology , immunology , leptin , ecology , endocrinology , genetics , obesity
The development and the maintenance of an efficient immune system represents a considerable metabolic investment for the organism. Ramond et al. have characterized a new molecular and cellular pathway, inhibiting the immune system in poor diet conditions in the Drosophila larva. Low nutrient conditions lead to the secretion of the adipokine NimB5 by the fat body, which inhibits the proliferation of the immune cells, hence preventing the exhaustion of the resources.