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Regulation of CHK1 by the Ubiquitin–Proteasome System
Author(s) -
Cartel Maëlle,
Didier Christine
Publication year - 2020
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15173
Subject(s) - ubiquitin ligase , regulator , microbiology and biotechnology , proteasome , biology , ubiquitin , chek1 , cell cycle , mechanism (biology) , carcinogenesis , cell cycle checkpoint , g2 m dna damage checkpoint , computational biology , genetics , cell , gene , philosophy , epistemology
The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al . provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to replicative stress. These results may help us to apprehend the underlying mechanism of tumorigenesis.