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New oncogenic signalling pathway: EWS‐Oct4 mediates bone and soft tissue tumourigenesis by activating fibroblast growth factor‐4
Author(s) -
Chen Dongmei,
Lee Tae Ho
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15023
Subject(s) - biology , transactivation , transcription factor , fusion protein , oncogene proteins , cancer research , fusion gene , microbiology and biotechnology , genetics , gene , regulation of gene expression , recombinant dna
Chromosomal translocations involving the interchange of parts between two non-homologous chromosomes can often lead to cancer by creating new fusion proteins. Here, Kim and co-workers show that a chimeric protein, EWS-Oct-4, transcriptionally activates fibroblast growth factor-4 (FGF-4) and triggers a downstream cascade of oncogenic signalling pathways, thereby facilitating the initiation of human bone and soft tissue tumour development. Comment on: https://doi.org/10.1111/febs.14946.