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A new mechanism for translational control in plants
Author(s) -
Miller W. Allen,
DineshKumar Savithramma P.
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.15022
Subject(s) - eif4e , translational regulation , translation (biology) , initiation factor , messenger rna , protein biosynthesis , mechanism (biology) , ribosome , posttranslational modification , phosphorylation , microbiology and biotechnology , biology , computational biology , biochemistry , physics , enzyme , rna , gene , quantum mechanics
In unstressed conditions, the cap‐binding protein, eIF 4E, binds the 5′ cap structure (m7G) on mRNA and recruits other translation initiation factors to bring the ribosome to the mRNA . Bruns et al . show that, in plants, phosphorylation of eIF 4E by the master metabolic regulatory protein, sucrose nonfermenting‐related kinase 1 (Sn RK 1), reduces translation globally. This negative regulation of translation inhibits geminivirus infection and is speculated to be a response to various abiotic stresses.