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A new approach to discovery of S100 protein heterodimers
Author(s) -
Garcia Velia,
Chazin Walter J.
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14851
Subject(s) - s100 protein , calcium binding protein , dimer , computational biology , protein family , biology , chemistry , genetics , calcium , gene , immunology , immunohistochemistry , organic chemistry
S100 proteins are a sub‐family of EF‐hand calcium binding proteins that form very similar, unique dimer structures. Although the possibility has been known for many years, no systematic study of the formation of S100 protein heterodimers has been reported. Shaw and coworkers demonstrate the application of a new approach that provides an in‐depth evaluation of the distribution of S100 protein homo‐ and heterodimer and show that the prevalence of heterodimers may be much higher than previously anticipated.