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Regulation of mitochondrial ROS production by HIC ‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?
Author(s) -
Doppler Wolfgang,
JansenDürr Pidder
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14746
Subject(s) - microbiology and biotechnology , reactive oxygen species , nadph oxidase , nox4 , senescence , reprogramming , chemistry , intracellular , oncogene , biology , biochemistry , cell , cell cycle
Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species (mtROS) via NADPH oxidase 4 ( NOX 4) is implicated in this process. Hydrogen peroxide‐inducible clone‐5 (HIC‐5) is postulated to sense both matrix detachment of transformed cells and intracellular ROS and can inhibit ras signaling via inhibition of NOX 4.