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Insights into the role of endoplasmic reticulum stress in skin function and associated diseases
Author(s) -
Park Kyungho,
Lee Sang Eun,
Shin KyongOh,
Uchida Yoshikazu
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14739
Subject(s) - unfolded protein response , endoplasmic reticulum , microbiology and biotechnology , pathogenesis , programmed cell death , apoptosis , protein folding , function (biology) , immunology , biology , medicine , cancer research , genetics
Endoplasmic reticulum ( ER ) stress is a mechanism that allows the protection of normal cellular functions in response to both internal perturbations, such as accumulation of unfolded proteins, and external perturbations, for example redox stress, UVB irradiation, and infection. A hallmark of ER stress is the accumulation of misfolded and unfolded proteins. Physiological levels of ER stress trigger the unfolded protein response ( UPR ) that is required to restore normal ER functions. However, the UPR can also initiate a cell death program/apoptosis pathway in response to excessive or persistent ER stress. Recently, it has become evident that chronic ER stress occurs in several diseases, including skin diseases such as Darier's disease, rosacea, vitiligo and melanoma; furthermore, it is suggested that ER stress is directly involved in the pathogenesis of these disorders. Here, we review the role of ER stress in skin function, and discuss its significance in skin diseases.