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PTP 1B markedly promotes breast cancer progression and is regulated by miR‐193a‐3p
Author(s) -
Yu Mengchao,
Liu Zhijian,
Liu Yuan,
Zhou Xinyan,
Sun Feng,
Liu Yanqing,
Li Liuyi,
Hua Shiyu,
Zhao Yi,
Gao Haidong,
Zhu Zhouting,
Na Muhan,
Zhang Qipeng,
Yang Rong,
Zhang Jianguo,
Yao Yongzhong,
Chen Xi
Publication year - 2019
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14724
Subject(s) - protein tyrosine phosphatase , oncogene , cancer research , biology , microrna , apoptosis , cancer , cell growth , phosphorylation , microbiology and biotechnology , gene , cell cycle , genetics
The protein tyrosine phosphatase PTP 1B, which is encoded by PTPN 1, is a ubiquitously expressed nonreceptor protein tyrosine phosphatase. PTP 1B has long been known to negatively regulate insulin and leptin receptor signalling. Recently, it was reported to be aberrantly expressed in cancer cells and to function as an important oncogene. In this study, we found that PTP 1B protein levels are dramatically increased in breast cancer (BC) tissues and that PTP 1B promotes the proliferation, and suppresses the apoptosis, of both HER 2‐positive and triple‐negative BC cell lines. Bioinformatics analysis identified that the mi RNA , miR‐193a‐3p, might potentially target PTP 1B. We demonstrate that miR‐193a‐3p regulates PTP 1B in BC cells and that it regulates the proliferation and apoptosis of BC cells by targeting PTP 1B, both in vitro and in vivo. In conclusion, this study confirms that PTP 1B acts as an oncogene in BC and demonstrates that miR‐193a‐3p can serve as a tumour suppressor gene in BC by targeting PTP 1B.