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Genetic interaction between DNA replication and the Notch signaling pathway
Author(s) -
Maduro Morris F.
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14584
Subject(s) - notch signaling pathway , microbiology and biotechnology , replication (statistics) , dna replication , hes3 signaling axis , signal transduction , dna , biology , genetics , chemistry , virology
The Notch pathway is a widely conserved cell signaling system found in most metazoans. In Caenorhabditis elegans , GLP ‐1/Notch signaling is required for developmental cell fate decisions in multiple contexts. A recent report provides a potential link between DNA replication and Notch‐dependent proliferation in the C. elegans germline.