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A guide to miRNAs in inflammation and innate immune responses
Author(s) -
Nejad Charlotte,
Stunden H. James,
Gantier Michael P.
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14482
Subject(s) - microrna , innate immune system , biology , inflammation , context (archaeology) , immunity , immune system , immunology , gene , neuroscience , genetics , paleontology
The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every cellular and developmental process in eukaryotic organisms. In the context of infection and immunity, miRNAs play critical roles controlling processes involved in pathogen clearance, while ensuring a rapid return to homeostasis. In this review, we provide a broad overview of the miRNAs that have been implicated in innate immunity and inflammation in mammals over the past decade. We discuss how most miRNAs can have dual activities on inflammation, suggesting that modulation of their activity for therapeutic purposes may be context‐dependent.