DUSPs, twists and turns in the Journey to Vascular Inflammation | Zendy

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DUSPs, twists and turns in the Journey to Vascular Inflammation

Author(s) -

Bennett Anton M.

Publication year - 2018

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.14461

Subject(s) - dusp6 , downregulation and upregulation , mapk/erk pathway , microbiology and biotechnology , inflammation , phosphatase , dual specificity phosphatase , signal transduction , chemistry , biology , phosphorylation , immunology , protein phosphatase 2 , biochemistry , gene

The MAPK phosphatase DUSP 6/ MKP ‐3 dephosphorylates ERK 1 and 2 and negatively regulates ERK ‐dependent signaling. Hsu et al . now show that DUSP 6/ MKP ‐3 is required for the TNF ‐α‐induced upregulation of the endothelial cell adhesion molecule‐1 ( ICAM ‐1) and neutrophil infiltration in endothelial cells, and interestingly, this positive role of DUSP 6 on the inflammatory process is independent of ERK signaling.

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