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DUSPs, twists and turns in the Journey to Vascular Inflammation
Author(s) -
Bennett Anton M.
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14461
Subject(s) - dusp6 , downregulation and upregulation , mapk/erk pathway , microbiology and biotechnology , inflammation , phosphatase , dual specificity phosphatase , signal transduction , chemistry , biology , phosphorylation , immunology , protein phosphatase 2 , biochemistry , gene
The MAPK phosphatase DUSP 6/ MKP ‐3 dephosphorylates ERK 1 and 2 and negatively regulates ERK ‐dependent signaling. Hsu et al . now show that DUSP 6/ MKP ‐3 is required for the TNF ‐α‐induced upregulation of the endothelial cell adhesion molecule‐1 ( ICAM ‐1) and neutrophil infiltration in endothelial cells, and interestingly, this positive role of DUSP 6 on the inflammatory process is independent of ERK signaling.