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The Nem1/Spo7–Pah1/lipin axis is required for autophagy induction after TORC 1 inactivation
Author(s) -
Rahman Muhammad Arifur,
Mostofa Md. Golam,
Ushimaru Takashi
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14448
Subject(s) - autophagy , microbiology and biotechnology , biogenesis , chemistry , function (biology) , vacuole , lipid droplet , biology , biochemistry , cytoplasm , gene , apoptosis
Autophagy is a process that requires intense membrane remodeling and consumption. The nutrient‐responsive TORC 1 (target of rapamycin complex 1) kinase regulates autophagy. However, how TORC 1 controls autophagy via lipid/membrane biogenesis is unknown. TORC 1 regulates the function of yeast phosphatidate phosphatase lipin Pah1 via the Nem1/Spo7 phosphatase complex. Here, we show that the Nem1/Spo7–Pah1 axis is required for autophagy induction after TORC 1 inactivation and survival during starvation. Furthermore, this axis was critical for nucleophagy (both micronucleophagy and macronucleophagy) and was required for proper localization of micronucleophagy factor Nvj1 and macronucleophagy receptor Atg39. This study indicated that the Nem1/Spo7–Pah1 axis controlled by TORC 1 is a critical branch for autophagy induction in nutrient starvation conditions.