Premium
Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?
Author(s) -
Escoll Pedro,
Buchrieser Carmen
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14446
Subject(s) - warburg effect , reprogramming , biology , microbiology and biotechnology , cancer cell , intracellular parasite , immune system , intracellular , cellular metabolism , metabolism , bacteria , host (biology) , cell , cancer , immunology , biochemistry , genetics
The finding that the Warburg effect observed in proliferating cancer cells is also observed during immune responses renewed the interest in the study of metabolic reprogramming of immune cells, a field of investigation called immunometabolism. However, the specific mechanisms and processes underlying metabolic changes of host cells upon bacterial infection remain poorly understood. Several recent reports have reported that mammalian cells infected with intracellular bacteria have an altered metabolism that resembles the Warburg effect seen in cancer cells. In this Review, we will summarize current knowledge on metabolic reprogramming and discuss putative causes underlying the preferential remodelling of host cells to Warburg‐like metabolic programs during infection by intracellular bacteria.