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IKK s and tumor cell plasticity
Author(s) -
Göktuna Serkan I.,
Diamanti Michaela A.,
Chau Tieu Lan
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14444
Subject(s) - iκb kinase , proinflammatory cytokine , transcription factor , tumor microenvironment , nf κb , metastasis , carcinogenesis , microbiology and biotechnology , biology , cancer research , cytokine , nfkb1 , signal transduction , tumor progression , tumor cells , immunology , inflammation , cancer , genetics , gene
Nuclear factor κB ( NF ‐κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF ‐κB signaling influences many aspects of tumor development, from initiation to metastasis. These functions are mediated by tumor‐induced plasticity that allows tumor cells to adapt and survive in changing conditions within the tumor microenvironment. Tumor cell plasticity is shaped by the inflammatory microenvironment in tumors. This review focuses on inhibitor of NF ‐κB kinases, the direct upstream elements of NF ‐κB regulation, specifically on their conventional and non‐conventional functions in animal models of tumorigenesis from the recent literature.