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Arteriovenous specification: BMPER and TWSG 1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
Author(s) -
OsmanagicMyers Selma,
Rezniczek Günther A.
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14439
Subject(s) - notch signaling pathway , microbiology and biotechnology , vasculogenesis , angiogenesis , sprouting angiogenesis , notch proteins , signal transduction , jag1 , hes3 signaling axis , biology , ephrin , chemistry , progenitor cell , cancer research , stem cell , neovascularization
Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification.