Tumor‐derived exosomes modulate T cell function through transfer of RNA | Zendy

House Imran G. | Zendy; Petley Emma V. | Zendy; Beavis Paul A. | Zendy

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Tumor‐derived exosomes modulate T cell function through transfer of RNA

Author(s) -

House Imran G.,

Petley Emma V.,

Beavis Paul A.

Publication year - 2018

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.14413

Subject(s) - microvesicles , immune system , cytotoxic t cell , tumor microenvironment , downregulation and upregulation , biology , adoptive cell transfer , exosome , cancer research , antigen presentation , immunology , t cell , microbiology and biotechnology , microrna , in vitro , biochemistry , gene

Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al ., in this edition of The FEBS Journal , make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.

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