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Tumor‐derived exosomes modulate T cell function through transfer of RNA
Author(s) -
House Imran G.,
Petley Emma V.,
Beavis Paul A.
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14413
Subject(s) - microvesicles , immune system , cytotoxic t cell , tumor microenvironment , downregulation and upregulation , biology , adoptive cell transfer , exosome , cancer research , antigen presentation , immunology , t cell , microbiology and biotechnology , microrna , in vitro , biochemistry , gene
Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al ., in this edition of The FEBS Journal , make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.