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Rubicon: LC 3‐associated phagocytosis and beyond
Author(s) -
Wong SingWai,
Sil Payel,
Martinez Jennifer
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14354
Subject(s) - autophagy , phagocytosis , regulator , microbiology and biotechnology , phagosome , endosome , extracellular , biology , replication (statistics) , intracellular , genetics , virology , gene , apoptosis
Rubicon ( Rubcn ) was initially identified as a component of the Class III PI 3K complex and a negative regulator of canonical autophagy and endosomal trafficking. However, Rubicon has attracted the most notoriety because of its critical role in LC 3‐associated phagocytosis ( LAP ), a form of noncanonical autophagy that utilizes some components of the autophagy machinery to process extracellular cargo. Additionally, Rubicon has been identified as a key modulator of the inflammatory response and viral replication. In this review, we discuss the known functions of Rubicon in LAP and other signaling pathways and examine the disease pathologies associated with Rubicon dysfunction in animal models and humans.