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Viral oncoproteins and ubiquitination: accessing a cellular toolbox for modifying protein function
Author(s) -
Thomas Miranda,
Banks Lawrence
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14208
Subject(s) - ubiquitin , proteasome , microbiology and biotechnology , innate immune system , biology , function (biology) , viral replication , transcription factor , computational biology , virus , virology , immune system , genetics , gene
Human Papillomavirus oncoproteins directly target components of the Ubiquitin Proteasome System (UPS) and allow perturbation of multiple cellular processes linked to the control of apoptosis, transcription and innate immunity. This activity primarily creates an environment favourable for viral replication, but can contribute towards malignancy, thus highlighting the roles that manipulation of the UPS can play in the development of human cancers.