Viral oncoproteins and ubiquitination: accessing a cellular toolbox for modifying protein function | Zendy

Thomas Miranda | Zendy; Banks Lawrence | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Viral oncoproteins and ubiquitination: accessing a cellular toolbox for modifying protein function

Author(s) -

Thomas Miranda,

Banks Lawrence

Publication year - 2017

Publication title -

the febs journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.981

H-Index - 204

eISSN - 1742-4658

pISSN - 1742-464X

DOI - 10.1111/febs.14208

Subject(s) - toolbox , ubiquitin , function (biology) , microbiology and biotechnology , computational biology , protein function , biology , chemistry , virology , cancer research , computer science , biochemistry , gene , programming language

Human Papillomavirus oncoproteins directly target components of the Ubiquitin Proteasome System (UPS) and allow perturbation of multiple cellular processes linked to the control of apoptosis, transcription and innate immunity. This activity primarily creates an environment favourable for viral replication, but can contribute towards malignancy, thus highlighting the roles that manipulation of the UPS can play in the development of human cancers.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research