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Biogenesis of circular RNA s and their roles in cardiovascular development and pathology
Author(s) -
Li Mengyang,
Ding Wei,
Sun Teng,
Tariq Muhammad A.,
Xu Tao,
Li Peifeng,
Wang Jianxun
Publication year - 2018
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14191
Subject(s) - circular rna , rna , biogenesis , rna splicing , messenger rna , cardiac hypertrophy , biology , disease , nucleic acid structure , computational biology , microbiology and biotechnology , muscle hypertrophy , medicine , gene , pathology , genetics , endocrinology
Circular RNA s (circ RNA s) are a newly discovered type of RNA generated by back‐splicing of precursor mRNA and found in many species. They are, expressed in a tissue‐specific manner and fulfill regulatory activities in many biological processes. Recent research has revealed that circ RNA s play critical roles in the development and pathologies of the cardiovascular system. Some of these circ RNA s show aberrant expression and regulatory activities during heart disease including heart failure and cardiac infarction and hypertrophy. These findings suggest that circ RNA s might be a suitable target for the treatment and prevention of heart disease. In this review, we summarize the latest research on the biogenesis and functions of circ RNA s with emphasis on the regulatory roles of circ RNA s in the development and pathologies of the cardiovascular system.