Posters

Recently we have developed the new system for nanopipette navigation with feedback control. The ability to precisely move the nanopipette to target specific regions such as neuronal processes allows an unprecedented level of control of drug application. The speed of data acquisition positions this as a technology which may be suited to relatively high-throughput application in human neuronal preparations which would greatly facilitate drug discovery. This nanopipette navigation system can be used in combination with other techniques such as microinjection, electrochemical measurement, and patch-clamp recording. This has the potential to open new horizons in medicine and biology and could be of particular value to the pharmaceutical industry. We have demonstrated unique application of nanopipette as a sensor for local electrochemichal measurements. Nanopipette can be filled with a carbon using butan decomposition in argon atmospher as a result we get a disk-shaped nanoelectrode. We have developed the method of platinum deposition at the tip of nanoelectrode. Such probe with platinum can detect various oxidgen consuptions. As a demonstration we have shown the detection of oxygen photosynthesized by plant cell on light. Using nanopipette navigation system we can do electrochemical mapping of a living cell surface with nanoscale resolution.