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Autophagy regulates apoptosis on the level of the death‐inducing signalling complex
Author(s) -
Nowikovsky Karin,
Bergmann Michael
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14119
Subject(s) - autophagy , microbiology and biotechnology , signal transducing adaptor protein , trif , apoptosis , signalling pathways , signalling , mechanism (biology) , signal transduction , death domain , programmed cell death , chemistry , biology , innate immune system , immune system , immunology , biochemistry , toll like receptor , philosophy , epistemology
The interactions between apoptotic and autophagic proteins via the proteolytic systems are known mechanisms through which autophagy and apoptosis regulate each other. In this issue of The FEBS Journal , Gentle and colleagues propose a mechanism through which autophagy regulates the induction of apoptosis at the level of the TIR‐domain‐containing adaptor‐inducing interferon‐β (TRIF) in TLR signaling.