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Pup recycling regulates the proteasome
Author(s) -
Petchiappan Anushya,
Chatterji Dipankar
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14112
Subject(s) - proteasome , ubiquitin , degradation (telecommunications) , protein degradation , microbiology and biotechnology , bacteria , chemistry , biology , computational biology , biochemistry , computer science , genetics , gene , telecommunications
The Pup proteasome system (PPS) in bacteria is equivalent to the eukaryotic ubiquitin proteasome system (UPS) that allows controlled protein degradation. Unlike the UPS, however, the PPS machinery and regulation is still poorly understood. In this issue of The FEBS Journal , Gur and colleagues combine experimental and modelling analyses to show how the PPS maintains steady‐state levels of protein pupylation and consequently tightly controlled protein degradation.