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ADP ‐ribosylation: new facets of an ancient modification
Author(s) -
Palazzo Luca,
Mikoč Andreja,
Ahel Ivan
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14078
Subject(s) - nucleic acid , dna damage , multicellular organism , adp ribosylation , dna , signal transduction , biology , dna repair , dna replication , transcription (linguistics) , eukaryotic cell , microbiology and biotechnology , transcription factor , cell , genetics , biochemistry , enzyme , gene , nad+ kinase , linguistics , philosophy
Rapid response to environmental changes is achieved by uni‐ and multicellular organisms through a series of molecular events, often involving modification of macromolecules, including proteins, nucleic acids and lipids. Amongst these, ADP ‐ribosylation is of emerging interest because of its ability to modify different macromolecules in the cells, and its association with many key biological processes, such as DNA ‐damage repair, DNA replication, transcription, cell division, signal transduction, stress and infection responses, microbial pathogenicity and aging. In this review, we provide an update on novel pathways and mechanisms regulated by ADP ‐ribosylation in organisms coming from all kingdoms of life.