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Histone methylation is critical in monocyte to macrophage differentiation
Author(s) -
Bermick Jennifer,
Schaller Matthew,
Carson William
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14074
Subject(s) - histone , histone methylation , chromatin , epigenetics , monocyte , microbiology and biotechnology , transcription factor , transcription (linguistics) , biology , dna methylation , genetics , gene expression , gene , linguistics , philosophy
Monocyte derived macrophages contribute to many human diseases, and a prescribed set of transcription factors control the differentiation of monocytes into macrophages. In this issue of The FEBS Journal , Jin and colleagues demonstrate that histone methylation changes in monocytes alter chromatin structure and ultimately direct the expression of numerous transcription factors crucial in this differentiation process.