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A new class of ribozyme from hepatitis B virus
Author(s) -
Lim Chun Shen,
Brown Christopher
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14062
Subject(s) - ribozyme , polyadenylation , cleavage (geology) , virology , hepatitis b virus , hairpin ribozyme , biology , virus , microbiology and biotechnology , rna , genetics , gene , paleontology , fracture (geology)
In this issue, Chakraborty and Ghosh present initial in vitro data indicating a 53‐base part of the hepatitis B virus ( HBV ) epsilon region is a ribozyme with unusual properties. Self‐cleavage first occurred at the HBV non‐canonical polyadenylation signal UAUAAA and the “centre bulge” of the epsilon region, releasing a ribozyme. The released ribozyme then acted as a new class of trans‐cleaving ribozyme cleaving other RNA s.