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There is something about BOK we just don't get yet
Author(s) -
Haschka Manuel D.,
Villunger Andreas
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14031
Subject(s) - cytochrome c , liposome , mitochondrion , family member , apoptosis , fern , bcl 2 family , chemistry , microbiology and biotechnology , biology , biochemistry , medicine , botany , programmed cell death , family medicine
Fernández‐Marrero and colleagues show in their work that the proapoptotic BCL ‐2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL ‐ X L . Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID .