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Integration of cellular ubiquitin and membrane traffic systems: focus on deubiquitylases
Author(s) -
Clague Michael J.,
Urbé Sylvie
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14007
Subject(s) - ubiquitin , endocytic cycle , microbiology and biotechnology , autophagy , organelle , sorting , membrane , biology , cell , endocytosis , computer science , biochemistry , apoptosis , gene , programming language
The cell is comprised of integrated multilevel protein networks or systems. The ubiquitin, protein homeostasis and membrane trafficking systems are highly integrated. Here, we look at the influence of reversible ubiquitylation on membrane trafficking and organelle dynamics. We review the regulation of endocytic sorting, selective autophagy and the secretory pathway by ubiquitin signals, with a particular focus on detailing the contribution of deubiquitylating enzymes.