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The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”
Author(s) -
Hardy John
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.14004
Subject(s) - amyloid precursor protein , cloning (programming) , disease , memoir , gene , biology , alzheimer's disease , computational biology , genetics , neuroscience , medicine , computer science , art , pathology , programming language , art history
The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress was not smooth, however, and many errors were made. In this memoir, I lay out both the progress and the errors.