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Phosphatidylinositol‐3‐phosphate in the regulation of autophagy membrane dynamics
Author(s) -
Nascimbeni Anna Chiara,
Codogno Patrice,
Morel Etienne
Publication year - 2017
Publication title -
the febs journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.981
H-Index - 204
eISSN - 1742-4658
pISSN - 1742-464X
DOI - 10.1111/febs.13987
Subject(s) - autophagy , autophagosome , phosphatidylinositol , endoplasmic reticulum , microbiology and biotechnology , biogenesis , pi , biology , kinase , biochemistry , apoptosis , gene
Phosphatidylinositol‐3‐phosphate ( PI 3P) is a key player in membrane dynamics and trafficking regulation. Most PI 3P is associated with endosomal membranes and with the autophagosome preassembly machinery, presumably at the endoplasmic reticulum. The enzyme responsible for most PI 3P synthesis, VPS 34 and proteins such as Beclin1 and ATG 14L that regulate PI 3P levels are positive modulators of autophagy initiation. It had been assumed that a local PI 3P pool was present at autophagosomes and preautophagosomal structures, such as the omegasome and the phagophore. This was recently confirmed by the demonstration that PI 3P‐binding proteins participate in the complex sequence of signalling that results in autophagosome assembly and activity. Here we summarize the historical discoveries of PI 3P lipid kinase involvement in autophagy, and we discuss the proposed role of PI 3P during autophagy, notably during the autophagosome biogenesis sequence.